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Abstract illustration of a glowing DNA strand on a dark blue background.

Research Services

DNA Methylation Microarray

Applications

  • Understanding the functional mechanisms at work in complex disease.

  • Detecting altered methylation patterns and epigenetic changes that provide insight into tumorigenic pathways and cancer progression.

  • Investigating the host methylation to infectious diseases.

DNA Methylation Analysis for Epigenome-Wide Association Studies

DNA methylation at the C5 position of cytosine plays a crucial role in gene expression and chromatin remodeling. Perturbations in methylation patterns are associated with tumorigenesis, neurodegenerative diseases and neurological disorders. Bioinformatic analysis of methylomes is widely used in various research areas, including studies on gene regulation, cell differentiation, embryogenesis, aging, occurrence and development of disease, phenotypic diversity and evolution in plants and animals.

AGTC Genomics

What's Included

  • Sample Receipt and Initial QC

  • Library Construction and QC

  • Sequencing and Data Delivery

  • Bioinformatics Analysis

Input Requirements

  • 200-250ng of DNA (20ng/µL)

Data Deliverable

  • Identifying differentially methylated CpGs

  • Clustering Analysis

  • Functional analysis

  • GeneSet Enrichment Analysis

Box plots and Venn diagram showing severity and cell proportions in the experiment.

Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection. Nat Commun 2022, 13(1):4597.

Collaborate with us

AGTC Genomics collaborates with researchers to apply genomics, multi-omics, and data-driven insights across discovery, translation, and development—accelerating innovation and real-world health impact.

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